In a significant move towards drug policy reform, the city of Berkeley, California, has officially decriminalized the possession of certain psychedelic substances. This includes psilocybin mushrooms, commonly known as magic mushrooms, and ayahuasca, a traditional spiritual medicine from the Amazon region. The Berkeley City Council unanimously passed the resolution, which makes the enforcement of laws against these substances among the lowest priority for the city’s law enforcement. This decision mirrors a similar move made by the city of Santa Cruz in early 2020, and it follows a growing trend across the United States toward the decriminalization and potential therapeutic use of psychedelic substances. Psilocybin mushrooms and ayahuasca are both known for their potent hallucinogenic effects. However, recent research has suggested that these substances may have potential therapeutic benefits, particularly in the treatment of mental health disorders such as depression and post-traumatic stress disorder (PTSD). The resolution in Berkeley does not, however, legalize the sale or commercial production of these substances. It also does not decriminalize other psychedelic substances such as LSD or MDMA, though it does call for the decriminalization of all entheogenic plants, which are plants used in religious or spiritual practices for their psychoactive effects. This decision by Berkeley represents a significant shift in the perception of psychedelic substances, moving away from a purely criminal perspective towards one that recognizes their potential therapeutic value. It also highlights the growing acceptance of alternative approaches to mental health treatment, particularly in a time when mental health issues are on the rise. While the move is seen as progressive by many, it also raises questions about the potential risks and challenges associated with the wider use of these substances. As such, it underscores the need for continued research and careful regulation to ensure the safe and effective use of these potentially powerful therapeutic tools.